Front mat / floor liners have been discussed before and it seems Weather tech and Husky are the two brands that have custom cut options.
Just got this floor liner. https://www.huskyliners.com/WeatherBeater-Floor-Mats/2011/ford/e-450-super-duty/2011/ford/e-450-super-duty
It's a big continuous U-shaped liner that is cut out to fit around the dog house and provides a little coverage for the area between the seats. I took these pics right after installing. I am hoping the area between the seats settles a little. The rest of the liners fit snug into all the cracks / crevices flush with the floor and feels secure.
Just wanted to share the pics in case anyone is looking at this as an option.
The other Husky option mentioned on the forum that seems to work for people has two separate mats - part # 33151 - https://www.huskyliners.com/Classic-Style-Floor-Mats/2017/ford/e-450-super-duty/2017/ford/e-450-super-duty
Still not sure I will like the U-shape vs two separate mats. Time will tell.
Time will tell how